Unprescribed Opioid Substitution Therapy

When used therapeutically under medical supervision for opioid dependence, methadone can alleviate withdrawal symptoms and reduce cravings. However, when abused or used without proper medical guidance, methadone can lead to a range of adverse effects, including:

• Pain relief
• Respiratory depression
• Euphoria and sedation
• Constipation
• Tolerance and dependence
• Cardiovascular damage
• Hormonal effects
• Immunosuppression

Street methadone and buprenorphine may come in various forms, including tablets, capsules, or liquid solutions. They can resemble prescription medications but may be obtained without a legitimate prescription. The appearance of these drugs can vary depending on the source and manufacturing process.

These drugs are typically ingested orally, either by swallowing tablets or capsules or by consuming liquid formulations. Some individuals may also inject these drugs intravenously, although this carries additional risks, including transmission of bloodborne infections and overdose.

• Street methadone and buprenorphine pose significant risks to users, particularly when used outside of medical supervision:
• Overdose: These drugs can cause respiratory depression and overdose, especially when taken in high doses or combined with other central nervous system depressants like alcohol or benzodiazepines.
• Dependency: Prolonged use of street methadone or buprenorphine can lead to physical dependence, tolerance, and withdrawal symptoms upon cessation.
• Adulterants: Illicitly obtained drugs may be contaminated/cut with unknown substances or adulterants, increasing the risk of adverse reactions and health complications.

• Whenever possible, obtain methadone or buprenorphine through legitimate medical channels, such as MAT programs or healthcare providers.
• If obtaining these drugs from the street, exercise caution and try to obtain them from a trusted and reliable source. Be wary of counterfeit or adulterated products.
• Use these drugs as directed by a healthcare professional and avoid taking larger doses or combining them with other substances.
• If experiencing adverse effects or concerns about dependence, seek medical assistance from a healthcare provider or addiction treatment specialist.
• By prioritizing safety and accessing appropriate support services, individuals can reduce the risks associated with street methadone and buprenorphine use and improve their overall well-being.